Immunophenotyping and Activation Status of Maternal Lymphocytes to Predict Spontaneous Preterm Birth in Women With Threatened Preterm Labor: A Prospective Observational Study.

Fiche publication

Date publication

décembre 2024

Journal

American journal of reproductive immunology (New York, N.Y. : 1989)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BARDOU Marc , Dr GARRIDO Carmen , Pr LIRUSSI Frédéric , Dr WENDREMAIRE Maeva

Tous les auteurs :
Wendremaire M, Hadi T, Lopez TE, Guy J, Neiers F, Garrido C, Simon E, Jaffal Z, Bernigal V, Bardou M, Lirussi F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39625044

Résumé

Preterm birth (PTB) remains the leading cause of neonatal morbidity and mortality. Identifying women at high risk of spontaneous preterm labor (PTL) is challenging due to limited efficient diagnostic markers. Since human parturition involves inflammatory immune processes, we hypothesized that phenotyping of maternal peripheral lymphocytes might predict PTL. Therefore, we aimed to explore the relationship between maternal lymphocyte subpopulations and labor onset characterized by delivery within 7 days of admission in women hospitalized for PTL between 24 and 34 weeks of gestation.