Protocol for a multicentre randomised triple-blind controlled trial assessing the clinical efficacy of intra-articular platelet-rich plasma injections versus placebo in symptomatic knee osteoarthritis (PIKOA).

Fiche publication

Date publication

novembre 2024

Journal

BMJ open

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ORNETTI Paul

Tous les auteurs :
Eymard F, Oubaya N, Ornetti P, Sellam J, Richette P, Chevalier X,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39615889

Résumé

Despite their exponential use, intra-articular (IA) injections of platelet-rich plasma (PRP) are not part of the recommended treatments for knee osteoarthritis (OA) by most international scientific societies. The most recent clinical trials have shown conflicting results, and some did not find any clinical benefit of PRP injections. The PRP In Knee OsteoArthritis (PIKOA) trial was designed to assess the clinical efficacy and structural benefit of IA injections of PRP vs saline solution (placebo) in symptomatic knee OA.