Individualized Prediction of Menses Recovery After Chemotherapy for Early-stage Breast Cancer: A Nomogram Developed From UNICANCER PACS04 and PACS05 Trials.

Date publication

février 2019

Journal

Clinical breast cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LORGIS Véronique

Tous les auteurs :
Pistilli B, Mazouni C, Zingarello A, Faron M, Saghatchian M, Grynberg M, Spielmann M, Kerbrat P, Roché H, Lorgis V, Bachelot T, Campone M, Levy C, Gonçalves A, Lesur A, Veyret C, Vanlemmens L, Lemonnier J, Delaloge S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30241966

Résumé

The likelihood of menses recovery varies greatly in premenopausal patients receiving adjuvant chemotherapy for breast cancer. Quantifying this probability for each patient could better inform the chemotherapy discussion and individualize fertility counseling. We performed a pooled analysis of the PACS04 and PACS05 adjuvant randomized trials to develop a nomogram to estimate the probability of menses recovery at 3, 6, and 18 months after the end of adjuvant chemotherapy.

Mots clés

Adjuvant chemotherapy, Chemotherapy induced amenorrhea, Early breast cancer, Menses recovery, Nomogram

Référence

Clin Breast Cancer. 2019 02;19(1):63-70