Fiche publication
Date publication
janvier 2025
Journal
Nature communications
Auteurs
Membres identifiés du Cancéropôle Est :
Dr JARRIAULT Sophie
Tous les auteurs :
Daniele T, Cury J, Morin MC, Ahier A, Isaia D, Jarriault S
Lien Pubmed
Résumé
Cell identity can be reprogrammed, naturally or experimentally, albeit with low frequency. Why some cells, but not their neighbours, undergo a cell identity conversion remains unclear. We find that Notch signalling plays a key role to promote natural transdifferentiation in C. elegans hermaphrodites. Endogenous Notch signalling endows a cell with the competence to transdifferentiate by promoting plasticity factors expression (hlh-16/Olig and sem-4/Sall). Strikingly, ectopic Notch can trigger additional transdifferentiation in vivo. However, Notch signalling can both promote and block transdifferentiation depending on its activation timing. Notch only promotes transdifferentiation during an early precise window of opportunity and signal duration must be tightly controlled in time. Our findings emphasise the importance of temporality and dynamics of the underlying molecular events preceding the initiation of natural cell reprogramming. Finally, our results support a model where both an extrinsic signal and the intrinsic cellular context combine to empower a cell with the competence to transdifferentiate.
Mots clés
Caenorhabditis elegans, metabolism, Animals, Cell Transdifferentiation, Receptors, Notch, metabolism, Caenorhabditis elegans Proteins, metabolism, Signal Transduction, Cellular Reprogramming
Référence
Nat Commun. 2025 01 2;16(1):75
