Personalized modeling of gut microbiome metabolism throughout the first year of life.

Date publication

décembre 2024

Journal

Communications medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis

Tous les auteurs :
Shaaban R, Busi SB, Wilmes P, Guéant JL, Heinken A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39739091

Résumé

Early-life exposures including diet, and the gut microbiome have been proposed to predispose infants towards multifactorial diseases later in life. Delivery via Cesarian section disrupts the establishment of the gut microbiome and has been associated with negative long-term outcomes. Here, we hypothesize that Cesarian section delivery alters not only the composition of the developing infant gut microbiome but also its metabolic capabilities. To test this, we developed a metabolic modeling workflow targeting the infant gut microbiome.

Référence

Commun Med (Lond). 2024 12 30;4(1):281