Fiche publication
Date publication
décembre 2024
Journal
BMC oral health
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent
Tous les auteurs :
Stutz C, Gegout PY, Bloch C, Özçelik H, Anton N, Tabti R, Désaubry L, Huck O, Petit C
Lien Pubmed
Résumé
Periodontitis is an inflammatory disease causing destruction of periodontal tissues. Controlling inflammation is crucial for periodontitis treatment. Prohibitins (PHBs) are emerging targets in the treatment of inflammatory diseases. To identify compounds that would alleviate periodontitis, several small molecules that directly target PHBs and display various pharmacological activities were screened to decrease Porphyromonas gingivalis induced inflammation. Indeed, IN44, a new PHB ligand that has been shown to inhibit STAT3 and NF-kB signaling, suggesting that it may alleviate periodontitis. This study aimed to assess IN44's impact on inflammation elicited by P. gingivalis.
Mots clés
Porphyromonas gingivalis, Infection, Inflammation, Periodontitis, Prohibitins
Référence
BMC Oral Health. 2024 12 21;24(1):1534
