Fiche publication
Date publication
janvier 2025
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie
,
Dr VELARD Frédéric
Tous les auteurs :
Dumortier C, Frauenpreis A, Hoarau A, Ryan AL, Gangloff SC, Danopoulos S, Velard F, Al Alam D
Lien Pubmed
Résumé
Cystic Fibrosis-related Bone Disease is an emerging challenge faced by 50 % of adult people with cystic fibrosis (CF). The multifactorial causes of this comorbidity remain elusive. However, congenital bone defects have been observed in animal models with CFTR mutations, suggesting its importance. The role of CFTR in bone cells development is unknown. Studies from human cells remain somewhat controversial depending on the cells used and the disease state of the patients from which the cells derived.
Mots clés
Cystic fibrosis-related bone disease, MSC, cell differentiation, iPSCs, osteoblasts
Référence
J Cyst Fibros. 2025 01 11;:
