Fiche publication
Date publication
janvier 2025
Journal
BJC reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DENAT Franck
Tous les auteurs :
Herbet A, Hautière M, Jean-Alphonse F, Vivier D, Leboeuf C, Costa N, Mabondzo A, Bousquet G, Denat F, Reiter E, Boquet D
Lien Pubmed
Résumé
Endothelin 1 receptors are one of the drivers of tumor progression in many cancers. Inhibition of their signaling pathways with antagonist drugs has been the subject of numerous clinical trials, but the results have not met expectations probably due to the high endothelin concentrations in the tumor microenvironment and their unusually high affinity for their receptors.
Référence
BJC Rep. 2025 01 20;3(1):3
