Fiche publication
Date publication
février 2025
Journal
JHEP reports : innovation in hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
,
Pr PESSAUX Patrick
,
Dr CROUCHET Emilie
Tous les auteurs :
Crouchet E, Almeida N, Durand SC, Parnot M, Oudot MA, Giannone F, Gadenne C, Roehlen N, Saviano A, Felli E, Pessaux P, Duong HT, Ohdan H, Aikata H, Chayama K, Baumert TF, Schuster C
Lien Pubmed
Résumé
Hepatocellular carcinoma (HCC) is the third-leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC are hampered by the absence of authentic tractable systems recapitulating the heterogeneity of HCC tumors in patients and the tumor microenvironment (TME).
Mots clés
3D model, Drug discovery and development, Immuno-oncology, Liver cancer, Tumor spheroids
Référence
JHEP Rep. 2025 02;7(2):101252