Fiche publication


Date publication

février 2025

Journal

JHEP reports : innovation in hepatology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas , Pr PESSAUX Patrick , Dr CROUCHET Emilie


Tous les auteurs :
Crouchet E, Almeida N, Durand SC, Parnot M, Oudot MA, Giannone F, Gadenne C, Roehlen N, Saviano A, Felli E, Pessaux P, Duong HT, Ohdan H, Aikata H, Chayama K, Baumert TF, Schuster C

Résumé

Hepatocellular carcinoma (HCC) is the third-leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC are hampered by the absence of authentic tractable systems recapitulating the heterogeneity of HCC tumors in patients and the tumor microenvironment (TME).

Mots clés

3D model, Drug discovery and development, Immuno-oncology, Liver cancer, Tumor spheroids

Référence

JHEP Rep. 2025 02;7(2):101252