Challenges of a tailored immunohistochemistry algorithm for uterine leiomyosarcoma: an integrated analysis of leiomyomas with bizarre nuclei and fumarate hydratase (FH) deficiency.

Fiche publication

Date publication

février 2025

Journal

Histopathology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ARNOULD Laurent , Dr AVEROUS Gerlinde

Tous les auteurs :
Alves-Vale C, Truffaux N, Velasco V, Azmani R, Alamé M, Rebier F, Mayeur L, Leger Y, Hostein I, Soubeyran I, Blanchard L, Marion E, Fontanges Q, Le Loarer F, Averous G, Genestie C, Arnould L, Devouassoux-Shisheboran M, Croce S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39961604

Résumé

Leiomyomas (LM) are the most common uterine mesenchymal neoplasms and encompass a variety of histological subtypes. Bizarre nuclei are described in both leiomyomas with bizarre nuclei (LM-BN) and fumarate hydratase-deficient leiomyomas (FH-LM), which raise diagnostic concerns regarding leiomyosarcoma (LMS). Recently, an immunohistochemical algorithm to support the diagnosis of LMS based on the genomic landscape of these neoplasms was proposed. This study aimed to evaluate the algorithm's accuracy in distinguishing LM-BN and FH-LM from LMS.