Modified Rankin Scale at 90 Days Versus National Institutes of Health Stroke Scale at 24 Hours as Primary Outcome in Acute Stroke Trials.

Date publication

février 2025

Journal

Journal of the American Heart Association

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUILLEMIN Francis

Tous les auteurs :
Ospel JM, Brown S, Bosshart S, Stebner A, Uchida K, Demchuk A, Saver JL, White P, Muir KW, Dippel DWJ, Majoie CBLM, Jovin TG, Campbell BCV, Mitchell PJ, Bracard S, Guillemin F, Hill M, Goyal M,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/39968801

Résumé

We investigate whether the National Institutes of Health Stroke Scale (NIHSS) at 24 hours could serve as a primary outcome in acute ischemic stroke trials, and whether combining 90-day modified Rankin Scale (mRS) and 24-hour NIHSS in a hierarchical outcome could enhance detection of treatment effect, using endovascular treatment (EVT) as an exemplary study intervention.

Mots clés

NIHSS, acute ischemic stroke, endovascular treatment, mRS, thrombectomy

Référence

J Am Heart Assoc. 2025 02 19;:e037752