Fiche publication
Date publication
février 2024
Journal
Cell reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SAVARY Stéphane
Tous les auteurs :
Parsons BD, Medina-Luna D, Scur M, Pinelli M, Gamage GS, Chilvers RA, Hamon Y, Ahmed IHI, Savary S, Makrigiannis AP, Braverman NE, Rodriguez-Alcazar JF, Latz E, Karakach TK, Di Cara F
Lien Pubmed
Résumé
Peroxisome biogenesis disorders (PBDs) represent a group of metabolic conditions that cause severe developmental defects. Peroxisomes are essential metabolic organelles, present in virtually every eukaryotic cell and mediating key processes in immunometabolism. To date, the full spectrum of PBDs remains to be identified, and the impact PBDs have on immune function is unexplored. This study presents a characterization of the hepatic immune compartment of a neonatal PBD mouse model at single-cell resolution to establish the importance and function of peroxisomes in developmental hematopoiesis. We report that hematopoietic defects are a feature in a severe PBD murine model. Finally, we identify a role for peroxisomes in the regulation of the major histocompatibility class II expression and antigen presentation to CD4 T cells in dendritic cells. This study adds to our understanding of the mechanisms of PBDs and expands our knowledge of the role of peroxisomes in immunometabolism.
Mots clés
CP: Cell biology, CP: Immunology, DAG, MCH class II, PKC-δ, antigen presentation, dendritic cells, immunometabolism, neonatal liver, peroxisome biogenesis disorders, peroxisomes, scRNA-seq
Référence
Cell Rep. 2024 02 27;43(2):113744
