Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes.

Date publication

mars 2023

Journal

BMC anesthesiology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHERKAOUI-MALKI Mustapha

Tous les auteurs :
Saxena S, Nuyens V, Rodts C, Jamar K, Albert A, Seidel L, Cherkaoui-Malki M, Boogaerts JG, Wulff H, Maze M, Kruys V, Vamecq J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/36927341

Résumé

Potassium channels (KCa3.1; Kv1.3; Kir2.1) are necessary for microglial activation, a pivotal requirement for the development of Perioperative Neurocognitive Disorders (PNDs). We previously reported on the role of microglial Kv1.3 for PNDs; the present study sought to determine whether inhibiting KCa3.1 channel activity affects neuroinflammation and prevents development of PND.

Mots clés

Anesthesia, Cognition, Inflammation, Microglia, Neuroinflammation, Perioperative neurocognitive disorders, Post-operative cognitive decline, Surgery

Référence

BMC Anesthesiol. 2023 03 16;23(1):80