Fiche publication
Date publication
janvier 2023
Journal
Trends in cell biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SAVARY Stéphane
Tous les auteurs :
Di Cara F, Savary S, Kovacs WJ, Kim P, Rachubinski RA
Lien Pubmed
Résumé
Peroxisomes are essential metabolic organelles, well known for their roles in the metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes have also been cast as central regulators of immunity. Lipid metabolites of peroxisomes, such as polyunsaturated fatty acids (PUFAs), are precursors for important immune mediators, including leukotrienes (LTs) and resolvins. Peroxisomal redox metabolism modulates cellular immune signaling such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activation. Additionally, peroxisomal β-oxidation and ether lipid synthesis control the development and aspects of the activation of both innate and adaptive immune cells. Finally, peroxisome number and metabolic activity have been linked to inflammatory diseases. These discoveries have opened avenues of investigation aimed at targeting peroxisomes for therapeutic intervention in immune disorders, inflammation, and cancer.
Mots clés
host–pathogen interaction, immune signaling, immunometabolism, peroxisome, phagocytosis
Référence
Trends Cell Biol. 2023 01;33(1):70-86
