Fiche publication
Date publication
février 2025
Journal
Biomarker research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HARLE Alexandre
,
Pr MERLIN Jean-Louis
,
Dr GILSON Pauline
Tous les auteurs :
Witz A, Dardare J, Betz M, Michel C, Husson M, Gilson P, Merlin JL, Harlé A
Lien Pubmed
Résumé
The use of poly(ADP-ribose) polymerase inhibitors (PARPi) revolutionized the treatment of BRCA-mutated cancers. Identifying patients exhibiting homologous recombination deficiency (HRD) has been proved useful to predict PARPi efficacy. However, obtaining HRD status remains an arduous task due to its evolution over the time. This causes HRD status to become obsolete when obtained from genomic scars, rendering PARPi ineffective for these patients. Only two HRD tests are currently FDA-approved, both based on genomic scars detection and BRCA mutations testing. Nevertheless, new technologies for obtaining an increasingly reliable HRD status continue to evolve. Application of these tests in clinical practice is an additional challenge due to the need for lower costs and shorter time to results delay.In this review, we describe the currently available methods for HRD testing, including the methodologies and corresponding tests for assessing HRD status, and discuss the clinical routine application of these tests and their technical validation.
Mots clés
BRCA mutations testing, Genomic scars analysis, HRD status, Homologous recombination deficiency, PARP inhibitors
Référence
Biomark Res. 2025 02 21;13(1):31