Protection in a model of liver injury is parallel to energy mobilization capacity under distinct nutritional status.

Fiche publication

Date publication

juin 2019

Journal

Nutrition (Burbank, Los Angeles County, Calif.)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHERKAOUI-MALKI Mustapha

Tous les auteurs :
Papegay B, Nuyens V, Albert A, Cherkaoui-Malki M, Leo O, Kruys V, Boogaerts JG, Vamecq J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31479844

Résumé

Dietary and energetic restrictions are endowed with protection against experimental injuries. However, a drop in cell energetic status under a critical threshold may prevent protection, as previously observed for livers isolated from rat donors undergoing 18-h fasting versus feeding. The aim of this study was to further explore, in the latter model, links between nutritional status, energy availability, and protection through lengthening of rat fasting to 24 h and withdrawal of energy sources from perfusions.