Fiche publication
Date publication
mars 2019
Journal
Materials science & engineering. C, Materials for biological applications
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SMEKTALA Frédéric
Tous les auteurs :
Mishra A, Désévédavy F, Petit L, Smektala F, Massera J
Lien Pubmed
Résumé
Recently, a phosphate glass with composition 20 CaO-20 SrO-10 NaO-50 PO (mol%) was found to have good potential as a biomaterial and to possess thermal properties suitable for fiber drawing. This study opened the path towards the development of fully bioresorbable fibers promising for biosensing. In the past, this phosphate glass with CeO was found to increase the refractive index and the glass stability. Therefore, a new SrO-containing glass was prepared with 1 mol% of CeO and core fibers were drawn from it. A core-clad fiber was also processed, where the core was a Ce-doped glass and the clad undoped, to allow for total internal reflection. The mechanical properties of the core and core-clad fibers are discussed as a function of immersion time in TRIS-buffer solution. Finally, a sensing region was created, in the core-clad fiber, by etching the cladding using phosphoric acid. Then, the change in light transmission, upon immersion in TRIS-buffer solution, was quantified to assess the potential use of the novel core-clad fiber as a biosensor. Upon immersion in TRIS, the core-clad fiber was found to guide light effectively and to maintain a tensile strength of ~150-200 MPa up to 6 weeks in TRIS, clearly showing that this fiber has potential as a biosensing device.
Mots clés
Biosensing Techniques, Cerium, chemistry, Glass, chemistry, Phosphates, chemistry, Strontium, chemistry
Référence
Mater Sci Eng C Mater Biol Appl. 2019 03;96:458-465
