Early Perfusion [123I]FP-CIT SPECT Imaging With a 360-degree CZT Camera in Dementia With Lewy Bodies.

Date publication

février 2025

Journal

Clinical nuclear medicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr VERGER Antoine

Tous les auteurs :
Verger A, Imbert L, Cecchin D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40001306

Résumé

Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [123I]FP-CIT SPECT dopaminergic imaging, and diffuse [18F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.

Référence

Clin Nucl Med. 2025 02 26;: