Fiche publication
Date publication
mars 2025
Journal
Brain research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HAFFEN Emmanuel
Tous les auteurs :
Cramoisy S, Cabeza L, Ramadan B, Houdayer C, Haffen E, Belin D, Peterschmitt Y, Bourasset F
Lien Pubmed
Résumé
Survival and well-being hinge on an organism's ability to evaluate options, weighing costs and benefits to make adaptive decisions. It has long been shown that stress influences cognition and reward-related behaviour, the nature of which depends on the stressor's type and duration as well as gene x environment interactions. However, how stress influence decision-making in females has not been completely elucidated. Here, we have developed a new mouse gambling task (mGT) adapted to assess decision-making under uncertainty and risk. Adult female C57BL/6JRj mice administered with corticosterone (CORT) for 5 or 8 weeks reached similar final performance in the mGT as vehicle-treated controls. All groups tended to learn to maximize gain as the task progressed. Our results revealed that individual choice kinetics is impacted by chronic exposure to CORT, showing an accentuated sensitivity to penalties in female mice. These results confirm the suitability of our new mGT to assess decision-making under uncertainty and risk and are in line with previous reports of the effect of chronic CORT treatment on decision-making in male mice. Thereby this study provides new insights into the influence of sex and stress on decision-making.
Référence
Brain Res. 2025 03 3;:149546
