Fiche publication
Date publication
février 2025
Journal
Revue des maladies respiratoires
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BONNIAUD Philippe
Tous les auteurs :
Biziorek L, Dériot M, Bonniaud P, Goirand F, Burgy O
Lien Pubmed
Résumé
Idiopathic pulmonary fibrosis (IPF) is a rare, progressive and fatal disease without pharmacologic curative treatments for the patients. TGF-β is a crucial cytokine in the fibrotic process, and its intracellular signaling pathways are complex and rely on the activation of its receptor. This review summarizes our knowledge on the regulatory checkpoints of the TGF-β signaling. In addition, the main strategies and key potential therapeutic targets identified over recent years are presented, with particular emphasis laid on how they can be used to develop new treatments for pulmonary fibrosis.
Mots clés
Cell signaling, Fibrose pulmonaire idiopathique, Idiopathic pulmonary fibrosis, Signalisation cellulaire, TGF-β
Référence
Rev Mal Respir. 2025 02 28;:
