Synthesis, Physicochemical Properties and Anti-Fungal Activities of New -Arylporphyrins.

Fiche publication

Date publication

février 2025

Journal

International journal of molecular sciences

Auteurs

Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline

Tous les auteurs :
Mkacher H, Chaâbane-Banaoues R, Hrichi S, Arnoux P, Babba H, Frochot C, Nasri H, Acherar S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40076639

Résumé

In this work, we describe the synthesis of three new -arylporphyrins, named -tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (), -tetrakis [4-(picolinoyloxy)phenyl] porphyrin (), and -tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (). These new synthesized -arylporphyrins are characterized using spectroscopic analysis: Fourier Transform Infrared Spectroscopy (FTIR) and One-dimensional Nuclear Magnetic Resonance (1D NMR), and mass spectrometry (MS). The photophysical studies (UV-visible absorption, singlet oxygen (O) luminescence, and fluorescence emissions) demonstrate their potential uses as photosensitizers (PSs) in photodynamic therapy (PDT) applications. An in vitro investigation of the anti-fungal activity of , , and against () species (, , and ) reveals that their minimum inhibitory concentration (MIC) values ranged from 1.25 to 5 mg/mL. In addition, their in vitro anti-fungal susceptibilities against three dermatophyte clinical isolates (, , and ) are also evaluated and they demonstrate good anti-fungal activities. A molecular docking study of these -arylporphyrins as anti-fungal agents against extracellular aspartic proteinases, Protein data Bank in Europe (PDBe code: 1J71) and Sialidases (PDBe code: 7P1D) underlines the possible interactions of , , and with the key amino acid residues of these fungal target proteins.