Cytoprotective and antioxidant properties of organic selenides for the myelin-forming cells, oligodendrocytes.

Fiche publication

Date publication

octobre 2018

Journal

Bioorganic chemistry

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ANDREOLETTI Pierre , Pr CHERKAOUI-MALKI Mustapha

Tous les auteurs :
Shaaban S, Vervandier-Fasseur D, Andreoletti P, Zarrouk A, Richard P, Negm A, Manolikakes G, Jacob C, Cherkaoui-Malki M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29864687

Résumé

Here a new series of twenty-one organoselenides, of potential protective activity, were synthesized and tested for their intrinsic cytotoxicity, anti-apoptotic and antioxidant capacities in oligodendrocytes. Most of the organoselenides were able to decrease the ROS levels, revealing antioxidant properties. Compounds 5b and 7b showed a high glutathione peroxidase (GPx)-like activities, which were 1.5 folds more active than ebselen. Remarkably, compound 5a diminished the formation of the oligodendrocytes SubG1 peak in a concentration-dependent manner, indicating its anti-apoptotic properties. Furthermore, based on the SwissADME web interface, we performed an in-silico structure-activity relationship to explore the drug-likeness of these organoselenides, predicting the pharmacokinetic parameters for compounds of interest that could cross the blood-brain barrier. Collectively, we present new organoselenide compounds with cytoprotective and antioxidant properties that can be considered as promising drug candidates for myelin diseases.