Fiche publication
Date publication
juillet 2018
Journal
Acta dermato-venereologica
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GRANEL-BROCARD Florence
Tous les auteurs :
Bohelay G, Blaise S, Levy P, Claeys A, Baudot N, Cuny JF, Maillard H, Granel-Brocard F, Boyé T, Lok C, Bénéton N, Francès C, Senet P
Lien Pubmed
Résumé
Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischaemic causes (arterial disease and/or microvascular impairment). A retrospective, multicentre, case-control study was conducted in 2013 and 2014, including 45 systemic sclerosis patients presenting lower-limb ulcers between 2008 and 2013. The estimated prevalence of lower-limb ulcers among systemic sclerosis patients was 12.8%. Ulcers were related to venous insufficiency in 22 cases (49%), ischaemic causes in 21 (47%) and other causes in 2 (4%). Complete healing was observed in 60% of cases in a mean time of 10.3 months; 59% relapsed during a mean follow-up of 22 months. Ischaemic lower-limb ulcer outcomes were poor, with a 28.6% amputation rate. Logistic-regression multivariate analyses between ischaemic lower-limb ulcer cases and matched systemic sclerosis-controls identified past or concomitant digital ulcer and cutaneous sclerosis of the feet as independent risk factors associated with ischaemic lower-limb ulcers.
Mots clés
Adult, Aged, Aged, 80 and over, Amputation, Surgical, Chi-Square Distribution, Disease Progression, Female, France, epidemiology, Humans, Ischemia, diagnosis, Leg Ulcer, diagnosis, Limb Salvage, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Prevalence, Recurrence, Retrospective Studies, Risk Factors, Scleroderma, Systemic, diagnosis, Time Factors, Treatment Outcome, Wound Healing, Young Adult
Référence
Acta Derm Venereol. 2018 07 11;98(7):677-682
