An overview on androgen-mediated actions in skeletal muscle and adipose tissue.

Fiche publication

Date publication

novembre 2023

Journal

Steroids

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DUTEIL Delphine

Tous les auteurs :
Rizk J, Sahu R, Duteil D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/37634653

Résumé

Androgens are a class of steroid hormones primarily associated with male sexual development and physiology, but exert pleiotropic effects in either sex. They have a crucial role in various physiological processes, including the regulation of skeletal muscle and adipose tissue homeostasis. The effects of androgens are mainly mediated through the androgen receptor (AR), a ligand-activated nuclear receptor expressed in both tissues. In skeletal muscle, androgens via AR exert a multitude of effects, ranging from increased muscle mass and strength, to the regulation of muscle fiber type composition, contraction and metabolic functions. In adipose tissue, androgens influence several processes including proliferation, fat distribution, and metabolism but they display depot-specific and organism-specific effects which differ in certain context. This review further explores the potential mechanisms underlying androgen-AR signaling in skeletal muscle and adipose tissue. Understanding the roles of androgens and their receptor in skeletal muscle and adipose tissue is essential for elucidating their contributions to physiological processes, disease conditions, and potential therapeutic interventions.