Brain-derived neurotrophic factor of the cerebral microvasculature: a forgotten and nitric oxide-dependent contributor of brain-derived neurotrophic factor in the brain.

Fiche publication

Date publication

avril 2017

Journal

Acta physiologica (Oxford, England)

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SAVARY Stéphane , Dr GONDCAILLE Catherine

Tous les auteurs :
Monnier A, Prigent-Tessier A, Quirié A, Bertrand N, Savary S, Gondcaille C, Garnier P, Demougeot C, Marie C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/27364224

Résumé

Evidence that brain-derived neurotrophic factor (BDNF), a neurotrophin largely involved in cognition, is expressed by cerebral endothelial cells led us to explore in rats the contribution of the cerebral microvasculature to BDNF found in brain tissue and the link between cerebrovascular nitric oxide (NO) and BDNF production.