Fiche publication
Date publication
mai 2019
Journal
Journal of analytical toxicology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MONASSIER Laurent
Tous les auteurs :
Ameline A, Greney H, Monassier L, Raul JS, Kintz P
Lien Pubmed
Résumé
In this article, two fatal cases related to the use of 3-methoxyphencyclidine (3-MeO-PCP) are described. This compound is a new psychoactive substance that belongs to the phencyclidine family. In the recent period, this dissociative drug has gained interest because of its proposal as a legally available alternative to phencyclidine in some countries. The scientific literature related to 3-MeO-PCP is very poor. Using standard ultra-performance liquid chromatography-mass spectrometry and ultra-performance liquid chromatography-tandem mass spectrometry, the authors focused on the detection of 3-MeO-PCP and its metabolites in human urine. 3-MeO-PCP metabolism was studied in vitro after drug incubation with human liver microsomes and the identified metabolites were investigated in the urine of the two forensic cases. 3-MeO-PCP metabolites, including O-demethyl-3-MeO-PCP, piperidine-hydroxy-3-MeO-PCP, O-demethyl-piperidine-di-hydroxy-3-MeO-PCP and piperidine-di-hydroxy-3-MeO-PCP, were detectable in the urine from both cases and the ratio between metabolites and parent 3-MeO-PCP, always lower than 1, were calculated to estimate the proportionality of metabolites. At this stage, one can conclude that testing for 3-MeO-PCP metabolites does not increase the window of detection of the drug.
Mots clés
Adult, Autopsy, Chromatography, Liquid, Designer Drugs, Drug Overdose, blood, Fatal Outcome, Female, Femoral Artery, Forensic Toxicology, Hallucinogens, blood, Humans, Illicit Drugs, blood, In Vitro Techniques, Male, Microsomes, Liver, drug effects, Osmolar Concentration, Phencyclidine, analogs & derivatives, Substance Abuse Detection, Tandem Mass Spectrometry
Référence
J Anal Toxicol. 2019 05 1;43(4):321-324
