Fiche publication
Date publication
mai 2018
Journal
Circulation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ZOLL Joffrey
Tous les auteurs :
Diguet N, Trammell SAJ, Tannous C, Deloux R, Piquereau J, Mougenot N, Gouge A, Gressette M, Manoury B, Blanc J, Breton M, Decaux JF, Lavery GG, Baczkó I, Zoll J, Garnier A, Li Z, Brenner C, Mericskay M
Lien Pubmed
Résumé
Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide adenine dinucleotide (NAD) is emerging as a metabolic target in a number of diseases including heart failure. Little is known on the mechanisms regulating homeostasis of NAD in the failing heart.
Mots clés
NAD, acetyl coenzyme A, cardiomyopathy, dilated, energy metabolism, glycolysis, heart failure, nicotinamide-beta-riboside, serum response factor
Référence
Circulation. 2018 05 22;137(21):2256-2273
