Fiche publication
Date publication
mars 2025
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul
Tous les auteurs :
Gabarre P, Palacios R, Perez K, Seksik P, Bonnard B, Loens C, Lefranc C, de Barros JP, Anjou L, Tamzali Y, Zahr N, Jaisser F, Tourret J
Lien Pubmed
Résumé
Kidney transplant recipients are prescribed an immunosuppressive therapy (IST) and some of them follow a high fat diet (HFD) despite medical recommendations. Both are frequently associated with gut microbiota changes and metabolic disorders. We aimed at precisely identifying the effect of the IST and the HFD on metabolic parameters and the gut microbiota in mice, and at establishing correlations between the latters.
Mots clés
Gastrointestinal Microbiome, drug effects, Animals, Male, Mice, Diet, High-Fat, adverse effects, Immunosuppressive Agents, pharmacology, Mice, Inbred C57BL, Diabetes Mellitus, microbiology, Insulin Resistance, Cardiometabolic Risk Factors, Cardiovascular Diseases, etiology, Feces, microbiology
Référence
PLoS One. 2025 03 28;20(3):e0320438
