Fiche publication
Date publication
avril 2025
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MERLIN Jean-Louis
,
Dr CORTESE Sophie
,
Dr MASTRONICOLA Romina
Tous les auteurs :
Mastronicola R, Kayser E, Le Roux P, Barrat A, Aubertin A, Casse A, Nominé L, Villard H, Cortese S, Beulque E, Merlin JL, Dolivet G
Lien Pubmed
Résumé
Distant metastasis in head and neck cancer are one of the first factors contributing to death. Currently, it is difficult to detect them early with our conventional techniques such as Positron Emission Tomography scanner (PET-scanner) and Magnetic Resonance Imaging (MRI). Therefore, it is important to find new markers that can help us in the care of the patient. This study aimed at comparing two methods (Reverse Transcription-Polymerase Chain Reaction and CellSearch) to detect circulating tumor cells (CTC) as a prognosticator. Results were statistically significant for markers EphB4 (p-value = 0.0003), CEA (p-value = 0.0006), CK 18 (p-value = 0.0011) and Ep-CAM (p-value = 0.0299) and demonstrate that our detection techniques could be used by optimizing our protocol. In addition, results of the rate of CTCs helped identify this as an indicator of a prognosis for the patient. Indeed, the study revealed that most patients in remission exhibited a decrease in post-operative CTCs, whereas patients experiencing relapses demonstrated an increase in CTCs, which was correlated with a poor prognosis.
Mots clés
Humans, Neoplastic Cells, Circulating, pathology, Head and Neck Neoplasms, pathology, Male, Female, Middle Aged, Prognosis, Aged, Biomarkers, Tumor, blood, Adult
Référence
PLoS One. 2025 04 1;20(4):e0320485
