Fiche publication
Date publication
mars 2025
Journal
Antiviral research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VERRIER Eloi
Tous les auteurs :
Eber C, Verrier ER
Lien Pubmed
Résumé
Janus kinases (JAKs) are key players in the innate immune response and inflammation, catalysing the phosphorylation of STAT proteins, which ultimately leads to the expression of pro-inflammatory and antimicrobial genes. In this context, specific inhibitors of JAK kinases, or JAKis, have been extensively developed, with some already in clinical use for the treatment of chronic inflammatory diseases. However, the interactions between JAK kinases and viral replication appear to be far more complex than initially expected, with some JAKis showing unexpected antiviral properties against different classes of viruses. This mini review summarizes current knowledge about the interactions between JAK proteins and viral infections and discusses the antiviral potential of JAK inhibitors in the development of innovative therapeutic strategies.
Référence
Antiviral Res. 2025 03 27;:106153
