Circulating Exosomal Proteins as New Diagnostic Biomarkers for Colorectal Cancer (EXOSCOL01): A Pilot Case-Controlled Study Focusing on MMP14 Potential.

Fiche publication

Date publication

avril 2025

Journal

Journal of clinical laboratory analysis

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BOUCHE Olivier , Dr BRASSART-PASCO Sylvie , Pr RAMONT Laurent , Dr BRASSART Bertrand

Tous les auteurs :
Barhoum M, Brassart-Pasco S, Dupont-Deshorgue A, Thierry A, Kanagaratnam L, Brassart B, Ramaholimihaso F, Botsen D, Carlier C, Brugel M, Perrier M, Ramont L, Bouché O

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/40244893

Résumé

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. The French CRC screening campaign is based on fecal immunochemical tests (FIT), confirmed by colonoscopy, an invasive procedure with a poor participation rate. This study aimed to compare the expression of circulating exosomal proteins (MMP14, β1-Integrin subunit, β3-Integrin subunit, and α1(I) Collagen chain) in patients with CRC or adenomas.