Treatment of adult ALL with central nervous system involvement at diagnosis using autologous and allogeneic transplantation: a study from the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire.

Date publication

mai 2013

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DECONINCK Eric

Tous les auteurs :
Chantepie SP, Mohty M, Tabrizi R, Robin M, Deconinck E, Buzyn A, Contentin N, Raus N, Lheritier V, Reman O

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/23165497

Résumé

To assess the role of hematopoietic SCT (HSCT) in adult ALL patients with central nervous system involvement at diagnosis, we retrospectively analyzed 90 patients who underwent autologous HSCT (auto-HSCT group; n=27) or allogeneic HSCT (allo-HSCT group; n=63) and reported to the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire registry between 1994 and 2008. At the time of transplantation, 67 patients (74%) were in first CR, 15 (17%) in CR>/=2 and 8 (9%) with progressive disease. The 5-year probabilities of overall survival (OS) and disease-free survival (DFS) were 52% and 46% for the allo-HSCT and 37% and 33% for the auto-HSCT groups, respectively (P=NS). The TRM at 5 years was 29.8% for the allo-HSCT group and 3.7% for the auto-HSCT group. Using univariate analysis, a time for transplantation of

Référence

Bone Marrow Transplant. 2013 May;48(5):684-90