5'- vs. 3'-end sugar conformational control in shaping up dinucleotides.

Date publication

juillet 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUILLAUME Dominique

Tous les auteurs :
Jakhlal J, Coantic-Castex S, Denhez C, Petermann C, Martinez A, Harakat D, Guillaume D, Clivio P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26140549

Résumé

The 5'-end N-sugar puckering is currently believed to govern the intramolecular dinucleotide stacking. We demonstrate that if this 5'-conformation is indeed important in shaping up dinucleotide structures, the 3'-end sugar conformation can either potentiate or cancel the stacking capacity induced by the 5'-end N-sugar conformation.

Référence

Chem Commun (Camb). 2015 Jul 3.