Fiche publication
Date publication
janvier 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BADER Marie-France
,
Dr BAILLY Yannick
,
Dr GASMAN Stéphane
,
Dr CHASSEROT-GOLAZ Sylvette
,
Dr TOTH Petra
Tous les auteurs :
Houy S, Croise P, Gubar O, Chasserot-Golaz S, Tryoen-Toth P, Bailly Y, Ory S, Bader MF, Gasman S
Lien Pubmed
Résumé
Although much has been learned concerning the mechanisms of secretory vesicle formation and fusion at donor and acceptor membrane compartments, relatively little attention has been paid toward understanding how cells maintain a homeostatic membrane balance through vesicular trafficking. In neurons and neuroendocrine cells, release of neurotransmitters, neuropeptides, and hormones occurs through calcium-regulated exocytosis at the plasma membrane. To allow recycling of secretory vesicle components and to preserve organelles integrity, cells must initiate and regulate compensatory membrane uptake. This review relates the fate of secretory granule membranes after full fusion exocytosis in neuroendocrine cells. In particular, we focus on the potential role of lipids in preserving and sorting secretory granule membranes after exocytosis and we discuss the potential mechanisms of membrane retrieval.
Référence
Front Endocrinol (Lausanne). 2013 Oct 2;4:135
