Retinol-binding protein 4 is an independent factor associated with triglycerides and a determinant of very low-density lipoprotein-apolipoprotein B100 catabolism in type 2 diabetes mellitus.

Date publication

décembre 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PETIT Jean-Michel , Pr VERGES Bruno

Tous les auteurs :
Verges B, Guiu B, Cercueil JP, Duvillard L, Robin I, Buffier P, Bouillet B, Aho S, Brindisi MC, Petit JM

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/23087360

Résumé

OBJECTIVE: Retinol-binding protein 4 (rbp4) is an adipokine secreted by adipocytes and liver, whose levels are elevated in type 2 diabetes mellitus (T2DM). Plasma levels of rbp4 and triglycerides are strongly correlated in T2DM. However, we do not know whether this association is direct or indirect via liver fat content, and the link between rbp4 and triglyceride metabolism remains unknown. METHODS AND RESULTS: Liver fat measurement by proton spectroscopy was performed in 221 patients with T2DM, and an in vivo kinetic study with stable isotopes was carried out in 14 patients with T2DM. In multivariate analysis, triglycerides were associated positively with rbp4 (beta=0.273, P

Référence

Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):3050-7