Estrogen dependent activation function of ER beta is essential for the sexual behavior of mouse females.

Date publication

novembre 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHAMBON Pierre

Tous les auteurs :
Antal MC, Petit-Demouliere B, Meziane H, Chambon P, Krust A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/23150547

Résumé

We previously generated and characterized a genuine estrogen receptor (ER) beta-null mouse line (named ER beta(L-/L-)(ST)) and showed that ER beta(L-/L-)(ST) mice were sterile, due to an ovulation impairment in females and to an unknown reason in males, as their reproductive organs and spermatozoid motility appeared normal. We report here an assessment of the sexual behavior of ER beta(L-/L-)(ST) null mice. We found that ER beta(L-/L-)(ST) males display mildly impaired sexual behavior and that ER beta(L-/L-)(ST) females are significantly less receptive and less attractive than wild-type (WT) females. Decreased attractivity is also exhibited by ER beta AF2(0) but not by ER beta AF1(0) mutant females (females devoid of either AF2 or AF1 activation function of ER beta). Interestingly, by using an odor preference test, we have determined that the low attractiveness of ER beta(L-/L-)(ST)and ER beta AF2(0) females is related to a deficiency of a volatile chemosignal.

Référence

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19822-7