Fiche publication
Date publication
juillet 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles
Tous les auteurs :
Morel O, Mandry D, Micard E, Kauffmann C, Lamiral Z, Verger A, Chevalier-Mathias E, Mathias J, Karcher G, Meneroux B, Rossignol P, Marie PY
Lien Pubmed
Résumé
The rates of growth of medically treated abdominal aortic aneurysms (AAA) are difficult to determine, and relationships with parietal inflammation and with metabolic parameters from (18)F-FDG PET remain unclear. This (18)F-FDG PET sequential observational study was aimed at analyzing the metabolic changes accompanying the growth phases of medically treated AAA. METHODS: Thirty-nine patients (37 men; age [mean +/- SD], 71 +/- 12 y) exhibiting small and medically treated AAA (maximal diameter, 46 +/- 3 mm) underwent (18)F-FDG PET and CT angiography at baseline and 9 mo later. Clinical and imaging parameter correlates of the 9-mo increase in maximal diameter were investigated; these included (18)F-FDG maximal standardized uptake values (SUVmax) averaged for slices encompassing the AAA volume. RESULTS: Of the 39 patients, 9 (23%) had a significant (>/=2.5 mm) increase in maximal diameter at 9 mo, whereas the remaining 30 did not. The patients with an increase in maximal diameter at 9 mo exhibited lower SUVmax within the AAA at baseline than patients who did not have such an increase (1.80 +/- 0.45 vs. 2.21 +/- 0.52; P = 0.04); they also displayed a trend toward greater changes in SUVmax at 9 mo (difference between 9 mo and baseline: +0.40 +/- 0.85 vs. -0.06 +/- 0.57; P = 0.07). Similar levels were ultimately reached in both groups at 9 mo (2.20 +/- 0.83 and 2.15 +/- 0.66). SUVmax was a significant, yet modest, baseline predictor of the absolute change in maximal diameter during follow-up (P = 0.049). CONCLUSION: The enhancement in the maximal diameter of small AAA was preceded by a stage with a low level of (18)F-FDG uptake, but this low level of uptake was no longer documented after the growth phases, suggesting a pattern of cyclic metabolic changes.
Référence
J Nucl Med. 2015 Jul;56(7):1030-5
