AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome.

Date publication

juillet 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GHIRINGHELLI François

Tous les auteurs :
Bullon P, Alcocer-Gomez E, Carrion AM, Garrido-Maraver J, Marin-Aguilar F, Roman-Malo L, Ruiz-Cabello J, Culic O, Ryffel B, Apetoh L, Ghiringhelli F, Battino M, Sanchez-Alcazar JA, Cordero MD

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26132721

Résumé

AIMS: Impairment in AMP-activated protein kinase (AMPK) activity and NLRP3-inflammasome activation are associated with several metabolic and inflammatory diseases. Herein, we investigated the role of AMPK/NLRP3-inflammasome axis in the molecular mechanism underlying pain perception. RESULTS: Impairment in AMPK activation induced by Compound C or sunitinib, two AMPK inhibitors, provoked hyperalgesia in mice (P

Référence

Antioxid Redox Signal. 2015 Jul 1.