Stretch-induced biodegradation of polyelectrolyte multilayer films for drug release.

Date publication

septembre 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe , Dr VOEGEL Jean-Claude , Pr SCHAAF Pierre , Dr MERTZ Damien

Tous les auteurs :
Barthes J, Mertz D, Bach C, Metz-Boutigue MH, Senger B, Voegel JC, Schaaf P, Lavalle P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22957730

Résumé

The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation of the film. This strategy is successfully applied for the release in solution of an anticancer drug initially loaded within the architecture.

Référence

Langmuir. 2012 Sep 25;28(38):13550-4