Acipimox-enhanced (1)(8)F-fluorodeoxyglucose positron emission tomography for characterizing and predicting early remodeling in the rat infarct model.

Date publication

août 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles

Tous les auteurs :
Bousquenaud M, Maskali F, Poussier S, Marie PY, Boutley H, Karcher G, Wagner DR, Devaux Y

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22116590

Résumé

The rat myocardial infarction (MI) model is widely used to study left ventricular (LV) remodeling. In this study, acipimox-enhanced (18)F-Fluorodeoxyglucose (FDG) gated-positron emission tomography (PET) was assessed for characterizing and predicting early remodeling in the rat infarct model. Nineteen Wistar rats had surgical occlusion of the left anterior descending coronary artery and 7 were sham-operated. PET was scheduled 48 h and 2 weeks later for quantifying MI area and LV function. Segments with 35% of LV) in 6 rats, moderate (15-35% of LV) in 8 rats, limited (

Référence

Int J Cardiovasc Imaging. 2012 Aug;28(6):1407-15