Fiche publication
Date publication
juin 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline
,
Dr VANDERESSE Régis
Tous les auteurs :
Stallivieri A, Le Guern F, Vanderesse R, Meledje E, Jori G, Frochot C, Acherar S
Lien Pubmed
Résumé
This article describes a new synthetic method for obtaining three water soluble porphyrins. The more sophisticated porphyrin [5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide], also named C12 porphyrin, was obtained through a three step methodology. The improvements, compared to syntheses described in the literature, mostly concern the purification procedures. The photophysical properties of the three porphyrins are described and the C12 porphyrin presents a very good 1O2 yield compared to its chemical intermediates. This porphyrin seems to be a very promising candidate for PDT applications.
Référence
Photochem Photobiol Sci. 2015 Jun 11.
