Fiche publication
Date publication
juin 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr EGLY Jean-Marc
,
Dr COMPE Emmanuel
Tous les auteurs :
Compe E, Egly JM
Lien Pubmed
Résumé
The transcription initiation factor TFIIH is a remarkable protein complex that has a fundamental role in the transcription of protein-coding genes as well as during the DNA nucleotide excision repair pathway. The detailed understanding of how TFIIH functions to coordinate these two processes is also providing an explanation for the phenotypes observed in patients who bear mutations in some of the TFIIH subunits. In this way, studies of TFIIH have revealed tight molecular connections between transcription and DNA repair and have helped to define the concept of 'transcription diseases'.
Référence
Nat Rev Mol Cell Biol. 2012 May 10;13(6):343-54
