[Post-thymus transplant vitiligo in a child with Foxn1 deficiency].

Date publication

juin 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard , Pr ENTZ-WERLE Natacha , Pr LIPSKER Dan

Tous les auteurs :
Levy E, Neven B, Entz-Werle N, Cribier B, Lipsker D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22721479

Résumé

BACKGROUND: Foxn1 transcription factor deficit leads to immune deficiency, with hair and nail abnormalities. We report the case of a patient also presenting localized leucoderma. CASE REPORT: A 3-year-old boy underwent thymus transplantation at the age of 9 months for Foxn1 deficiency. He had developed urticaria and autoimmune hypothyroidism after thymus grafting. On examination, he had universal non-scarring alopecia, nail changes (atrophy, partial onycholysis and longitudinal grooves) and leucoderma on both big toes. DISCUSSION: This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation. The pathogenic hypotheses discussed were post-graft vitiligo and leucoderma induced by Foxn1 deficiency.

Référence

Ann Dermatol Venereol. 2012 Jun;139(6-7):468-71