A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation.

Date publication

avril 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Dr TORA Laszlo , Pr VIVILLE Stéphane

Tous les auteurs :
Kamieniarz K, Izzo A, Dundr M, Tropberger P, Ozretic L, Kirfel J, Scheer E, Tropel P, Wisniewski JR, Tora L, Viville S, Buettner R, Schneider R

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22465951

Résumé

The linker histone H1 is a key player in chromatin organization, yet our understanding of the regulation of H1 functions by post-translational modifications is very limited. We provide here the first functional characterization of H1 acetylation. We show that H1.4K34 acetylation (H1.4K34ac) is mediated by GCN5 and is preferentially enriched at promoters of active genes, where it stimulates transcription by increasing H1 mobility and recruiting a general transcription factor. H1.4K34ac is dynamic during spermatogenesis and marks undifferentiated cells such as induced pluripotent stem (iPS) cells and testicular germ cell tumors. We propose a model for H1.4K34ac as a novel regulator of chromatin function with a dual role in transcriptional activation.

Référence

Genes Dev. 2012 Apr 15;26(8):797-802