Fiche publication
Date publication
janvier 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FRISCH Benoit
,
Dr VOEGEL Jean-Claude
,
Pr SCHAAF Pierre
Tous les auteurs :
Davila J, Chassepot A, Longo J, Boulmedais F, Reisch A, Frisch B, Meyer F, Voegel JC, Mesini PJ, Senger B, Metz-Boutigue MH, Hemmerle J, Lavalle P, Schaaf P, Jierry L
Lien Pubmed
Résumé
Cell adhesion processes take place through mechanotransduction mechanisms where stretching of proteins results in biological responses. In this work, we present the first cyto-mechanoresponsive surface that mimics such behavior by becoming cell-adhesive through exhibition of arginine-glycine-aspartic acid (RGD) adhesion peptides under stretching. This mechanoresponsive surface is based on polyelectrolyte multilayer films built on a silicone sheet and where RGD-grafted polyelectrolytes are embedded under antifouling phosphorylcholine-grafted polyelectrolytes. The stretching of this film induces an increase in fibroblast cell viability and adhesion.
Référence
J Am Chem Soc. 2012 Jan 11;134(1):83-6
