Exclusive image guided IMRT vs. radical prostatectomy followed by postoperative IMRT for localized prostate cancer: a matched-pair analysis based on risk-groups.

Date publication

janvier 2012

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CORMIER Luc , Dr MARTIN Etienne , Dr MIRJOLET Céline , Dr PEIGNAUX Karine , Pr TRUC Gilles

Tous les auteurs :
Azelie C, Gauthier M, Mirjolet C, Cormier L, Martin E, Peignaux-Casasnovas K, Truc G, Chamois J, Maingon P, Crehange G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22978763

Résumé

BACKGROUND: To investigate whether patients treated for a localized prostate cancer (PCa) require a radical prostatectomy followed by postoperative radiotherapy or exclusive radiotherapy, in the modern era of image guided IMRT. METHODS: 178 patients with PCa were referred for daily exclusive image guided IMRT (IG-IMRT) using an on-line 3D ultra-sound based system and 69 patients were referred for postoperative IMRT without image guidance after radical prostatectomy (RP + IMRT). Patients were matched in a 1:1 ratio according to their baseline risk group before any treatment. Late toxicity was scored using the CTV v3.0 scale. Biochemical failure was defined as a postoperative PSA /= 2 toxicity in the IG-IMRT group vs. 4% in the RP + IMRT group. Forty two percent of the patients in both groups had late grade >/= 2 genitourinary toxicity. The 5-year FFF rates in the IG-IMRT group and in the RP + IMRT groups were 93.1% [80.0-97.8] and 76.5% [58.3-87.5], respectively (p = 0.031). CONCLUSIONS: Patients with a localized PCa treated with IG-IMRT had better oncological outcome than patients treated with RP + IMRT. Further improvements in postoperative IMRT using image guidance and dose escalation are urgently needed.

Référence

Radiat Oncol. 2012 Sep 17;7:158