Fiche publication
Date publication
novembre 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BINQUET Christine
,
Pr BONNIN Alain
,
Pr VILLENA Isabelle
Tous les auteurs :
Wallon M, Kieffer F, Binquet C, Thulliez P, Garcia-Meric P, Dureau P, Franck J, Peyron F, Bonnin A, Villena I, Bonithon-Kopp C, Gouyon JB, Masson S, Felin A, Cornu C
Lien Pubmed
Résumé
In France, children with confirmed congenital toxoplasmosis receive a treatment for a period of 12 to 24 months. Such prolonged treatment may generate potentially severe risks, in particular hematologic and cutaneous. Our objective is to compare the effectiveness of two therapeutic strategies on the prevention of retinochoroiditis by a randomized, non-inferiority, open-label, parallel study including 486 children, 3 to 6 months of age with a non-severe form of congenital toxoplasmosis. Following randomization, pyrimethamine-sulphonamide treatment is initiated for a period of three months, followed by a treatment with Fansidar((R)) for 9 months, or therapeutic abstention. Follow-up visits during a two-year period will include an examination of the eye, a blood test, and questionnaires to evaluate the children's quality of life and their parents' anxiety. Confirming the non-inferiority of the effectiveness of a short-term treatment will improve the quality of life of parents and children.
Référence
Therapie. 2011 Nov-Dec;66(6):473-80
