Association of IL1B polymorphism with left ventricular systolic dysfunction: a relation with the release of interleukin-1beta in stress condition.

Date publication

septembre 2011

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GUEANT Jean-Louis , Dr BATTAGLIA-HSU Shyue-Fang

Tous les auteurs :
Gueant-Rodriguez RM, Juilliere Y, Battaglia-Hsu SF, Debard R, Gerard P, Reyes P, Danchin N, Gueant JL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/21811191

Résumé

OBJECTIVE: Proinflammatory cytokines play a major role in the pathomechanisms of heart failure. Besides this, the influence of mental stress on heart failure is poorly documented despite its effects on sympathetic stimulation of interleukin-1beta (IL-1beta) secretion. We examined whether the polymorphisms of proinflammatory cytokines are predictors of left ventricular systolic dysfunction (LVSD) and if so, whether such associations are related to the secretion of these cytokines, in 572 consecutive patients under mental stress produced by coronary angiography. METHODS: We examined IL-1RN (VNTR), IL1A-889 C>T, IL1B-511 C>T, IL6-174 G>C and TNFA-308 G>A, according to LVSD (left ventricular ejection fraction,

Référence

Pharmacogenet Genomics. 2011 Sep;21(9):579-86.