Fiche publication
Date publication
avril 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BRUNOTTE François
Tous les auteurs :
Humbert O, Dygai-Cochet I, Gauthier M, Cochet A, Berriolo-Riedinger A, Crehange G, Toubeau M, Brunotte F
Résumé
The aim of this retrospective study was to investigate the prognostic significance of initial FDG-PET in patients with newly diagnosed oesophageal carcinoma before exclusive radiochemotherapy. FDG-PET was performed in 29 patients with newly diagnosed oesophageal carcinoma before radiochemotherapy. Maximum standardized uptake value (SUVmax) was determined in each primary lesion and the presence of one or more PET-positive lymph nodes was recorded. Primary tumour volume and tumour length were assessed using two different thresholds for tumour delimitation: SUV = 2.5 and SUV = 40% of SUVmax. Patients were followed clinically during at least 1 year after initial FDG-PET. The median follow-up was 35 months (IC 95% = 26-41 months). Thirteen patients (45%) died during the follow-up. By univariate logistic regression analysis, the SUVmax of primary tumour and the presence of one or more positive lymph nodes were significantly associated with the overall survival. In contrast, no significant difference of prognosis was observed concerning age, sex, tumour cell type, primary site, clinical stage, primary tumour volume and length. Multivariate analysis was not performed due to the too small number of events. FDG-PET provides early prognostic informations in oesophageal carcinoma treated by radiochemotherapy. (C) 2011 Elsevier Masson SAS. All rights reserved.
Référence
. 2011 Apr;35(4):186-94.
