Assessment of adrenal function in cirrhotic patients using concentration of serum-free and salivary cortisol.

Date publication

mars 2011

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent , Dr MINELLO Anne

Tous les auteurs :
Thevenot T, Borot S, Remy-Martin A, Sapin R, Cervoni JP, Richou C, Vanlemmens C, Cleau D, Muel E, Minello A, Tirziu S, Penfornis A, Di Martino V, Monnet E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/21281437

Résumé

OBJECTIVE: Because over 90% of serum cortisol is bound to albumin and corticosteroid-binding globulin (CBG), changes in these proteins can affect measures of serum total cortisol levels in cirrhotics without altering serum-free and salivary cortisol concentrations. METHODS: We assessed basal (T) and post-synacthen (T) serum total cortisol, serum-free and salivary cortisol in 125 consecutive cirrhotics (95 non-septic and 30 septic patients with a Child>8). RESULTS: Serum total cortisol levels significantly decreased from the Child A-C non-septic group, as did albumin and CBG levels, with a non-significant rise in serum-free cortisol concentrations. Non-septic patients with low albumin (

Référence

Liver Int. 2011 Mar;31(3):425-33